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Similar considerations as above can be repeated by replacing conductance and susceptance with resistance and reactance respectively. In microwave circuits, waves and scattering parameters are normally used instead of voltages, currents and impedance parameters. Equivalently, the network shown in Figure 5.3 is modi ed to the network as shown in Figure 5.5, and eqs. (5.1), (5.2), (5.9), (5.10) and (5.11) become b=

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Engineering in the 21st century will encounter very different problems from those seen today. In particular, it is apparent that concerns of sustainable development and pollution will become increasingly central to our work. By finding scientific ways of addressing these issues we can make a significant contribution to mankind. To this end, an understanding of our manmade and natural environment, particularly in terms of the interaction between the two, is crucial. One field that impinges on this understanding, from pollution movement in a city centre to the flow of avalanches, is fluid dynamics. Computer-aided analysis techniques have revolutionalized engineering design in many fields. Computational Fluid Dynamics (CFD) is one such technique which enables the analysis of fluid flow phenomena including heat transfer, mass transfer and chemical reaction. This is achieved by solving the mathematical equations which underlie the physical processes using a mesh based iterative solution method. CFD is principally used to study the behaviour of air

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As per FDA guidelines, changes in excipients (%w/w) of total formulation not greater than 5% are considered minor and all information is provided in the annual report. However, changes likely to have signi cant effect on the quality and performance of a drug product calls for submission of a prior approval supplement on all information (in vitro dissolution and in vivo dissolution), including accelerated stability and long-term stability testing in the annual report [4]. Similarly, in EU guidelines, a change in the batch size of the nished product up to10-fold compared to the original batch size approved at the grant of the marketing authorization (or downscaling to 10-fold) has been de ned as type IA and requires batch analysis data (in a comparative tabulated format) on a minimum of one production batch manufactured to both the currently approved and the proposed sizes. Batch data on the next two full production batches should be made available upon request and reported by the marketing authorization holder if outside speci cations (with proposed action). However, for type IB (more than 10-fold), in addition to the above

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This observation suggests that we form a cost function given a finite number of data vectors as follows:

conjugating mirror (PCM), a spatial lter (SF), and a frequency-selective element (FS). The PCM is a self-pumped photorefractive BaTiO3-crystal doped with 800 ppm rhodium and measures 5.1 5.5 5.3 mm3 (a a c). The spatial lter is placed in the pseudo-far- eld plane and consists of two razor blades that, when correctly adjusted, allow only a single spatial mode, (i.e., one array mode), to pass to be retrore ected by the PCM. The frequency-selective element is either a Fabry Perot etalon with a nesse of 2.6 or a diffraction grating with 1200 lines/mm. Both elements narrow the spectrum of the laser output to less than 0.01 nm when inserted into the phase conjugate feedback path in the external cavity. The single-mode output lobe produced by this system is extracted by a mirror (M1) in front of the spatial lter. The far- eld radiation pattern is narrowed down to 1.5 times the diffraction limit. For operation at current levels higher than two times threshold, the improvement of the coherence is less pronounced. This problem can be avoided using antire ection coating of the front facet of the laser diode array, whereby the in uence of the phase conjugate feedback at higher current levels is increased. Figure 9.13 shows the setup for external feedback measurements with spatial ltering in both the external feedback path and the phase conjugate feedback path. 9.5.1 Long-term stability of the phase conjugate laser system